Oxysterols in intestinal immunity and inflammation

TSLP regulates intestinal immunity and inflammation

This thesis characterizes and explores the role of thymic stromal lymphopoietin (TSLP) – TSLP receptor (TSLPR) interactions in the regulation of intestinal immunity and inflammation. TSLP is known to promote TH2 cytokine-mediated inflammation in the skin and the lung. Firstly, this thesis focuses on the characterization of TSLP and TSLPR expression within the gastrointestinal (GI) tract and in ...

Epithelial Cell Inflammasomes in Intestinal Immunity and Inflammation

Pattern recognition receptors (PRR), such as NOD-like receptors (NLRs), sense conserved microbial signatures, and host danger signals leading to the coordination of appropriate immune responses. Upon activation, a subset of NLR initiate the assembly of a multimeric protein complex known as the inflammasome, which processes pro-inflammatory cytokines and mediates a specialized form of cell death...

Special Issue: Cutting-Edge Research on Intestinal Immunity and Inflammation

Special Issue: Cutting-Edge Research on Intestinal Immunity and Inflammation

Research on intestinal epithelial stem cells has flourished in the last few years since their specific markers were identified. However, to exploit the potentials of those adult stem cells as a source for regenerative medicine, validation of the tissue regeneration capability of intestinal stem cells would be essential. We have recently shown that, by employing murine models of transplantation,...

Immune oxysterols: Role in mycobacterial infection and inflammation

Infection remains an important cause of morbidity and mortality. Natural defenses to infection are mediated by intrinsic/innate and adaptive immune responses. While our understanding is considerable it is incomplete and emerging areas of research such as those related to the immune-metabolic axis are only beginning to be appreciated. There is increasing evidence showing a connection between imm...